Rapid Incident Intake
Capture radiopharmaceutical, administered activity, estimated extravasated activity, administration timeline, injection location, available imaging, and relevant clinical observations.
Clinical Physics & Dosimetry
Extravasation Dosimetry & Incident Support
Independent absorbed-dose assessments for suspected radiopharmaceutical extravasations. From incident documentation to localized tissue and skin dosimetry, UpThera supports nuclear medicine teams with technical analysis and professional physics review.
Requests are sent from your UpThera account. Signing in is required.
Tissue & Skin Dosimetry
Support calculation of localized absorbed dose using documented MIRD methodology, measured or estimated activity retention, source geometry, and appropriate dose coefficients. Include uncertainty estimates and limitations.
Independent Physics Reporting
Generate preliminary technical summaries and support professionally reviewed, signed reports with calculation methods, assumptions, dose estimates, and regulatory review considerations.
Extravasation Assessment Workspace
Fictional example- Radiopharmaceutical
- Pluvicto (Lu-177)
- Incident
- Suspected extravasation
- Administered activity
- 7,400 MBq
- Estimated extravasated activity
- Pending assessment
- Clearance data
- Awaiting measurements
- Local tissue dose
- Not yet calculated
- Case status
- Physics review requested
Demonstration data, fictional. No patient. No dose has been calculated and no Medical Event determination is made by UpThera. Calculations are Research / Demonstration Only.
Incident intake
A secure intake, built for the facts a physicist needs
The request is sent from your facility account, and alerts your RSO, administrators and managers. Imaging files and survey records are attached to the request. No names, MRNs or dates of birth: cases are identified by your own incident reference.
Facility account
From your signed-in account, with your role and a contact for the physicist.
Required
Incident and requester
- Case referenceRequired
- Your roleRequired
- Administration dateRequired
- Administration start timeRequired
- Administration end timeOptional
- Time the extravasation was suspectedOptional
Radiopharmaceutical and activity
- RadionuclideRequired
- RadiopharmaceuticalRequired
- Prescribed activityRequired
- Administered activityRequired
- Estimated extravasated fraction or activityOptional
- Evidence for that estimateOptional
Injection site
- Injection locationRequired
- Vascular accessOptional
- Site dimensions and tissue-volume estimateOptional
- How the dimensions were obtainedOptional
- Symptoms and clinical observationsOptional
Measurements and imaging
- Available dataOptional
- Survey measurementsOptional
- Measurement timestampsOptional
- Follow-up measurementsOptional
- About follow-up measurementsOptional
Urgent consultation can be requested on the form. That marks the request urgent; it does not confirm that a physicist is available.
Dosimetry engine
Modular, documented, and not yet clinical
Pluvicto (Lu-177) is the first development scenario. Calculations stay disabled for clinical use until the numerical models are validated and approved for their intended use. Where validated data is missing, the result reads “Quantitative estimate unavailable — validated source data required.” Assessments today are prepared and signed by a medical physicist.
In the research workflow on each extravasation case, a physicist uploads the site’s time–activity curve, fits the effective clearance half-life with its 95% interval, scales counts with a measured retained activity, and estimates mean absorbed dose by local energy deposition from the tissue geometry and an energy per decay they enter with its source. The spread across clearance scenarios is shown beside the central value.
- 1
Decay & emission libraries
Half-lives and emission data with their source on every value. Lu-177 half-life from NNDC; emission data to be imported from an evaluated library.
- 2
Activity-versus-time curve
Upload the site’s curve as CSV. A log-linear fit gives the effective and biological half-lives with a 95% interval. Assumed clearance is named as an assumption.
- 3
Time-integrated activity
Integration of the measured curve with the assumptions written out alongside the result.
- 4
Geometry-specific MIRD S-values
An S-value is used only with documented units, reference geometry, source and validation. No arbitrary mass scaling.
- 5
Local tissue absorbed dose
Combines time-integrated activity with a validated S-value for the stated geometry.
- 6
Skin-depth dosimetry
Dose at a stated skin depth from validated depth-dose data for the radionuclide and geometry.
- 7
Monte Carlo integration
An interface for a transport code to model the specific site geometry.
- 8
Sensitivity & uncertainty
The spread across clearance scenarios and input ranges, shown with the estimate.
Regulatory review
Medical Event Reporting Review
Reportability requires assessment of the applicable regulatory criteria, clinical circumstances, license conditions, and jurisdiction. Absorbed dose alone does not automatically determine Medical Event status.
UpThera never classifies an extravasation as a reportable Medical Event. It records the reviews and documentation of your people.
- RSO reviewThe criteria considered and the RSO’s conclusion, in their words, with who recorded it and when.
- Qualified medical physicist reviewThe physicist’s review of the dose assessment and its limitations.
- Regulatory documentationWhat was decided or filed, with dates, references and copies attached to the case.
Need an Independent Dose Assessment?
UpThera helps nuclear medicine teams evaluate suspected extravasations through specialized dosimetry and professional physics support.